Pancreatitis and PDAC: association and differentiation

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ID: 261500
2019
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Abstract
The discrimination of mass-forming chronic pancreatitis (MFCP) from pancreatic ductal adenocarcinoma (PDAC) is a central diagnostic dilemma. It is important to differentiate these entities since they have markedly different prognoses and management. Importantly, the appearance of these two entities significantly overlaps on a variety of imaging modalities. However, there are imaging features that may be suggestive of one entity more than the other. MFCP and PDAC may show different enhancement patterns on perfusion computed tomography (CT) and/or dynamic contrast-enhanced MRI (DCE-MRI). The duct-penetrating sign on magnetic resonance cholangiopancreatography (MRCP) is more often associated with MFCP, whereas abrupt cutoff with upstream dilatation of the main pancreatic duct and the double-duct sign (obstruction/cutoff of both the common bile duct and pancreatic duct) are more often associated with PDAC. Nevertheless, tissue sampling is the most reliable method to differentiate between these entities and is currently generally necessary for management.
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elsherif2019abdominalpancreatitis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sherif B. Elsherif;Mayur Virarkar;Sanaz Javadi;Juan J. Ibarra-Rovira;Eric P. Tamm;Priya R. Bhosale;Sherif B. Elsherif;Mayur Virarkar;Sanaz Javadi;Juan J. Ibarra-Rovira;Eric P. Tamm;Priya R. Bhosale;
Journal abdominal radiology
Year 2019
DOI
doi:10.1007/s00261-019-02292-w
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