A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment.

Clicks: 330
ID: 26150
2019
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Abstract
With the arrival of the precision medicine and personalized treatment era, targeted therapy that improves efficacy and reduces side effects has become the mainstream approach of cancer treatment. Antibody fragments that further enhance penetration and retain the most critical antigen-specific binding functions are considered the focus of research targeting cancer imaging and therapy. Thanks to the superior penetration and rapid blood clearance of antibody fragments, antibody fragment-based imaging agents enable efficient and sensitive imaging of tumour sites. In tumour-targeted therapy, antibody fragments can directly inhibit tumour proliferation and growth, serve as an ideal carrier for delivery of anti-tumour drugs, or manipulate the immune system to eliminate tumour cells. In this review, the excellent physicochemical properties and the basic structure of antibody fragments are expressly depicted , the progress of antibody fragments in cancer therapy and imaging are thoroughly summarized, and the future development of antibody fragments is predicted.
Reference Key
zhao2019aartificial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhao, Xuhong;Ning, Qian;Mo, Zhongcheng;Tang, Shengsong;
Journal artificial cells, nanomedicine, and biotechnology
Year 2019
DOI
10.1080/21691401.2019.1657875
URL
Keywords Keywords not found

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