Occupational exposure to asphalt fume can cause oxidative DNA damage among road paving workers.

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ID: 261366
2018
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Abstract
We designed the present study to determine the effect of occupational exposure to asphalt fumes on oxidative status and DNA damage in road paving workers.Sixty road paving workers exposed to asphalt fumes and forty non-exposed control subjects were recruited. Occupational exposure to PAHs was assessed by urinary 1-hydroxypyrene (1-OHP) excretion. Serum thiol disulfide homeostasis (TDH), total oxidant status (TOS) and total antioxidant status (TAS) and urinary 8-hydro-deoxyguanosine (8-OH-dG) level were evaluated by automated colourimetric method.The urinary concentrations of 1-OHP and 8-OH-dG were significantly higher in the exposed group than in the control group (P < 0.001). Disulfide/thiol ratio, TOS, and TAS were also significantly higher for the asphalt workers. A positive correlation existed between urinary 1-OHP and 8-OH-dG, TOS and TAS.Study results indicate that exposure to PAHs induces oxidative stress and causes genotoxic effects in asphalt workers.
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Authors Bal, Ceylan;Ağış, Erol R;Büyükşekerci, Murat;Gündüzöz, Meşide;Tutkun, Lütfiye;Yılmaz, Ömer H;
Journal American journal of industrial medicine
Year 2018
DOI
10.1002/ajim.22830
URL
Keywords
oxidative stress dna damage 8-hydro-deoxyguanosine pahs exposure asphalt pavers thiol disulfide homeostasis

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