De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities

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2019
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Abstract
De novo protein design represents an attractive approach for testing and extending our understanding of metalloprotein structure and function. Here, we describe our work on the design of DF (Due Ferri or two-iron in Italian), a minimalist model for the active sites of much larger and more complex na …
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Authors Lombardi A;Pirro F;Maglio O;Chino M;DeGrado WF;;
Journal accounts of chemical research
Year 2019
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/30973707
Keywords
catalysis National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural amino acid sequence sequence alignment ligands protein conformation binding sites angela lombardi iron / chemistry metalloproteins / chemistry* pmid:30973707 pmc7362765 doi:10.1021/acs.accounts.8b00674 fabio pirro william f degrado molecular docking simulation alpha-helical protein engineering / methods*

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