increased umbilical cord pai-1 levels in placental insufficiency are associated with fetal hypoxia and angiogenesis
Clicks: 150
ID: 260198
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
150 views
15 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #120 of 193 articles by views in international journal of psychology : journal international de psychologie
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 193 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
In intrauterine growth restriction (IUGR), a subset of pregnancies undergoes placental vascular dysregulation resulting in restricted blood flow and fetal hypoxemia. Altered transcription of hypoxic regulated plasminogen activator inhibitor 1 (PAI-1) has been associated with pregnancy complications and angiogenic regulation. Here we assessed circulating PAI-1 as an indicator of placental insufficiency. Venous umbilical PAI-1 of hypoxemic (VpO2 20 versus 35 mmHg, p<0.0001) placental insufficient pregnancies (resistance index 0.9 versus 0.63, p<0.05) (n=18) was compared to controls (n=12). PAI-1 was increased (~10-fold, p<0.001) and had a positive predictive ratio of 6.7. Further, PAI-1 levels correlated to blood oxygen (r=-0.68, p<0.0001). The plasma’s angiogenic potency measured in vitro was associated with umbilical cord blood PAI-1 levels (r=0.65, p<0.01). This association was attenuated by PAI-1 inhibiting antibody (p<0.001). The results demonstrate PAI-1 as a potential marker of placental insufficiency and identify its close association with pathological hypoxia and angiogenesis in a subset of growth restricted pregnancies.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (59 words).
Try re-searching for a better abstract.
| Reference Key |
seferovic2016diseaseincreased
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Maxim D. Seferovic;Madhulika B. Gupta |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2016 |
| DOI |
10.1155/2016/7124186
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.