using murine models to investigate tumor–lymphoid interactions: spotlight on chronic lymphocytic leukemia and angioimmunoblastic t-cell lymphoma

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ID: 260140
2017
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Abstract
The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin’s lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.
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cutucache2017frontiersusing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Christine E. Cutucache;Tyler A. Herek
Journal international journal of heat and technology
Year 2017
DOI
10.3389/fonc.2017.00086
URL
http://journal.frontiersin.org/article/10.3389/fonc.2017.00086/full
Keywords
lymphoma immune surveillance chronic lymphocytic leukemia Oncology including cancer and carcinogens tumors tumor-induced immunosuppressionneoplasms

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