assessment of olfactory threshold in patients undergoing radiotherapy for head and neck malignancies

Clicks: 111
ID: 259127
2014
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Abstract
Introduction: Radiotherapy is a common treatment modality for patients with head and neck malignancies. As the nose lies within the field of radiotherapy of the head and neck, the olfactory fibers and olfactory receptors may be affected by radiation. The aim of this study was to evaluate changes in olfactory threshold in patients with head and neck malignancies who have received radiation to the head and neck.   Materials and Methods: The olfactory threshold of patients with head and neck malignancies was assessed prospectively before radiation therapy and serially for up to 6 months after radiotherapy using sniff bottles. In vivo dosimetry was performed using 82 LiF (MCP) chips and a thermoluminescent dosimeter (TLD) system.   Results: Sixty-one patients were recruited before radiotherapy was commenced. Seven patients did not return for evaluation after radiation. Fifty-four patients were available for follow-up assessment (28 women, 26 men; age, 22–86 years; median, 49 years). Total radiation dose was 50.1 Gy (range, 30–66 Gy). Mean olfactory threshold scores were found to deteriorate significantly at various timepoints after radiotherapy (11.7 before radiotherapy versus 4.0 at Month 6, general linear model, P135 µC (Mann-Whitney U test, P=0.01).   Conclusion:  Deterioration in olfactory threshold scores was found at 6 months after initiation of radiation therapy. Provided that these results are reproducible, an evaluation of olfactory functioning in patients with head and neck malignancies using in vivo dosimetry may be useful for determining the optimal dose for patients treated with conformal radiotherapy techniques while avoiding the side effects of radiation.
Reference Key
jalali2014iranianassessment Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mir Mohammad Jalali;Hooshang Gerami;Abbas Rahimi;Manizheh Jafari
Journal safety science
Year 2014
DOI
DOI not found
URL
http://ijorl.mums.ac.ir/pdf_2865_ef267643ec32b07394d92875d601565b.html
Keywords
radiotherapy thermoluminescent dosimetryotorhinolaryngology

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