radio-immunotherapy-induced immunogenic cancer cells as basis for induction of systemic anti-tumor immune responses – preclinical evidence and ongoing clinical applications
Clics: 264
ID: 258419
2015
Metricas de Calidad y Rendimiento del Articulo
Calidad General
Improving Quality
0.0
/100
Combina datos de participacion con calidad academica evaluada por IA
Participacion del Lector
Emerging Content
30.0
/100
263 vistas
18 lectores
En Tendencia
Evaluacion de Calidad por IA
No analizado
Resumen
Radiotherapy (RT) primarily aims to locally destroy the tumor via the induction of DNA damage in the tumor cells. However, so called abscopal, namely systemic and immune mediated effects of RT move over more and more in the focus of scientists and clinicians since combinations of local irradiation with immune therapy have been demonstrated to induce anti-tumor immunity. We here summarize changes of the phenotype and microenvironment of tumor cells after exposure to irradiation, chemotherapeutic agents and immune modulating agents rendering the tumor more immunogenic. The impact of therapy-modified tumor cells and damage associated molecular patterns (DAMPs) on local and systemic control of the primary tumor, recurrent tumors and metastases will be outlined. Finally, clinical studies affirming the bench-side findings of interactions and synergies of radiation therapy and immunotherapy will be discussed. Focus is set on combination of radio(chemo)therapy (RCT) with immune checkpoint inhibitors, growth factor inhibitors and chimeric antigen receptor (CAR) T-cell therapy. Well deliberated combination of RCT with selected immune therapies and growth factor inhibitors bear the great potential to further improve anti-cancer therapies.
| Clave de Referencia |
ederer2015frontiersradio-immunotherapy-induced
Use esta clave para autocitar en el manuscrito mientras usa
SciMatic Manuscript Manager o Thesis Manager
|
|---|---|
| Autores | ;Anja eDerer;Lisa eDeloch;Yvonne eRubner;Rainer eFietkau;Benjamin eFrey;Udo S Gaipl |
| Revista | sudebno-meditsinskaia ekspertiza |
| Ano | 2015 |
| DOI |
10.3389/fimmu.2015.00505
|
| URL | |
| Palabras Clave |
Citas
No se encontraron citas. Para agregar una cita, contacte al administrador en info@scimatic.org
Comentarios
Aun no hay comentarios. Sea el primero en comentar este articulo.