chronic rhinosinusitis: potential role of microbial dysbiosis and recommendations for sampling sites

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ID: 257928
2018
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Abstract
Chronic rhinosinusitis (CRS) is an inflammatory condition that affects up to 12% of the human population in developed countries. Previous studies examining the potential role of the sinus bacterial microbiota within CRS infections have found inconsistent results, possibly because of inconsistencies in sampling strategies. The aim of this study was to determine whether the sinus microbiome is altered in CRS and additionally if the middle meatus is a suitable representative site for sampling the sinus microbiome. Swab samples were collected from 12 healthy controls and 21 CRS patients, including all eight sinuses for CRS patients and between one and five sinuses for control subjects. The left and right middle meatus and nostril swabs were also collected. Significant differences in the sinus microbiomes between CRS and control samples were revealed using high-throughput 16S rRNA gene sequencing. The genus Escherichia was over-represented in CRS sinuses, and associations between control patients and Corynebacterium and Dolosigranulum were also identified. Comparisons of the middle meatuses between groups did not reflect these differences, and the abundance of the genus Escherichia was significantly lower at this location. Additionally, intra-patient variation was lower between sinuses than between sinus and middle meatus, which together with the above results suggests that the middle meatus is not an effective representative sampling site.
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copeland2018frontierschronic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elizabeth Copeland;Katherine Leonard;Richard Carney;Justin Kong;Martin Forer;Yuresh Naidoo;Brian G. G. Oliver;Brian G. G. Oliver;Justin R. Seymour;Stephen Woodcock;Catherine M. Burke;Nicholas W. Stow;Nicholas W. Stow
Journal electronic physician
Year 2018
DOI
10.3389/fcimb.2018.00057
URL
http://journal.frontiersin.org/article/10.3389/fcimb.2018.00057/full
Keywords
16s rrna gene sequencing microbiome

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