neuromodulatory effects of caffeine and bromazepam on visual event-related potential (p300): a comparative study efeitos neuromoduladores da cafeína e do bromazepam no potencial evocado visual relacionado a evento (p300): estudo comparativo

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ID: 257416
2005
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Abstract
The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information. OBJECTIVE: To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database. METHOD: 15 right-handed individuals (7 male and 8 female), between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design. RESULTS: Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database. CONCLUSION: The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.
O componente P300 do potencial evocado relacionado a evento é uma medida geral de "eficiência cognitiva" e um índice da qualidade do processamento e armazenamento de informações pelo sistema nervoso central (SNC). OBJETIVO: Comparar os efeitos neuromoduladores da cafeína e do bromazepam a partir do banco normativo do potencial evocado visual (P300). MÉTODO: 15 sujeitos destros (7 homens e 8 mulheres), entre 20 e 30 anos de idade, sadios, livres de qualquer déficit cognitivo e sem uso de substâncias psicotrópicas ou psicoativas foram estudados. Os sujeitos foram submetidos a uma tarefa de discriminação visual utilizando o paradigma "oddball", após a administração de uma cápsula de cafeína ou de bromazepam, em um desenho duplo-cego randomizado. RESULTADOS: Foram observadas diferenças estatisticamente significativas quando as condições cafeína e bromazepam foram comparadas com o banco normativo. CONCLUSÃO: Os resultados sugerem que a cafeína e o bromazepam têm efeitos moduladores específicos no SNC.
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montenegro2005arquivosneuromodulatory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mariana Montenegro;Heloisa Veiga;Andréa Deslandes;Maurício Cagy;Kaleb McDowell;Fernando Pompeu;Roberto Piedade;Pedro Ribeiro
Journal communications in computer and information science
Year 2005
DOI
10.1590/S0004-282X2005000300009
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000300009
Keywords
caffeine event-related potential p300 neuropsychiatry biological psychiatry

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