neural correlates of rules and conflict in medial prefrontal cortex during decision and feedback epochs

Clicks: 313
ID: 256522
2015
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Abstract
The ability to properly adjust behavioral responses to cues in a changing environment is crucial for survival. Activity in the medial Prefrontal Cortex (mPFC) is thought to both represent rules to guide behavior as well as detect and resolve conflicts between rules in changing contingencies. However, while lesion and pharmacological studies have supported a crucial role for mPFC in this type of set-shifting, an understanding of how mPFC represents current rules or detects and resolves conflict between different rules is unclear. Here, we directly address the role of rat mPFC in shifting rule based behavioral strategies using a novel behavioral task designed to tease apart neural signatures of rules, conflict and direction. We demonstrate that activity of single neurons in rat mPFC represent distinct rules. Further, we show increased firing on high conflict trials in a separate population of mPFC neurons. Reduced firing in both populations of neurons was associated with poor performance. Moreover, activity in both populations increased and decreased firing during the outcome epoch when reward was and was not delivered on correct and incorrect trials, respectively. In addition, outcome firing was modulated by the current rule and the degree of conflict associated with the previous decision. These results promote a greater understanding of the role that mPFC plays in switching between rules, signaling both rule and conflict to promote improved behavioral performance.
Reference Key
bissonette2015frontiersneural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gregory B Bissonette;Gregory B Bissonette;Matthew eRoesch;Matthew eRoesch
Journal lasers in manufacturing and materials processing
Year 2015
DOI
10.3389/fnbeh.2015.00266
URL
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00266/full
Keywords
conflict set-shifting neuropsychiatry biological psychiatry rule encodingneurosciences

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