foreign or domestic cars: receptor ligands as antigen-binding domains

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ID: 256236
2014
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Abstract
Chimeric antigen receptors (CARs) are increasingly being used in clinical trials to treat a variety of malignant conditions and recent results with CD19-specific CARs showing complete tumor regressions has sparked the interest of researchers and the public alike. Traditional CARs have been generated using single-chain variable fragments (scFv), often derived from murine monoclonal antibodies, for antigen specificity. As the clinical experience with CAR T cells grows, so does the potential for unwanted immune responses against the foreign transgene. Strategies that may reduce the immunogenicity of CAR T cells are humanization of the scFv and the use of naturally occurring receptor ligands as antigen-binding domains. Herein, we review the experience with alternatively designed CARs that contain receptor ligands rather than scFv. While most of the experiences have been in the pre-clinical setting, clinical data is also emerging.
Reference Key
shaffer2014medicalforeign Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Donald R. Shaffer, Penghui Zhou, Stephen Gottschalk
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Journal the lancet global health
Year 2014
DOI
10.3390/medsci2010023
URL
http://www.mdpi.com/2076-3271/2/1/23
Keywords
immunology chimeric antigen receptor adoptive immunotherapy cancermedicine

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