from igg fusion proteins to engineered-specific human regulatory t cells: a life of tolerance

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2017
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Abstract
Recent efforts have concentrated on approaches to expand and “specify” human regulatory T cells (Tregs) and to apply them to modulate adverse immune responses in autoimmunity and hemophilia. We have used retroviral transduction of specific T-cell receptor, single chain Fv, or antigen domains in Tregs to achieve this goal. Each of these approaches have advantages and disadvantages. Results with these engineered T cells and evolution of the research developments and paths that led to the development of specific regulatory approaches for tolerance are summarized.
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Authors ;David W. Scott
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.01576
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01576/full
Keywords
multiple sclerosis chimeric antigen receptor regulatory t cells hemophilia a allergy b-cell receptorimmunologic diseases

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