antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes
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2003
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Abstract
Mixed tetraoxanes of the 4-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and antimycobacterials. The activity of the (4R or S)-phenyl series against P. falciparum D6 and W2 strains was found to be at the level of artemisinin, with two compounds, the acid 4 and the amide 6, exhibiting encouraging anti-TB activity as well. Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances, the activity against a selected number of cell lines was higher than that of the antitumor drug paclitaxel.
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| Authors | ;BOGDAN A. SOLAJA;DENNIS E. KYLE;DEJAN OPSENICA;WILBUR K. MILHOUS |
| Journal | meditsinskaia radiologiia |
| Year | 2003 |
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