induced foxp3+ t cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory t cells.

Clicks: 194
ID: 256011
2016
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Abstract
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3+Treg. Here we show that both in vitro and in vivo generated antigen specific Foxp3+Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.
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ehilbrands2016frontiersinduced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Robert eHilbrands;Ye eChen;Adrian eKendal;Elizabeth eAdams;Stephen Paul Cobbold;Herman eWaldmann;Duncan eHowie
Journal sudebno-meditsinskaia ekspertiza
Year 2016
DOI
10.3389/fimmu.2016.00124
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00124/full
Keywords
t cells transplantation foxp3 antigens allergy regulatory t cellsimmunologic diseases

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