age-related loss of muscle mass and strength

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ID: 255585
2012
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Abstract
Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis. Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF) which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that “kick start” local muscle repair and induces hypertrophy.
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goldspink2012journalage-related Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Geoffrey Goldspink
Journal Lancet (London, England)
Year 2012
DOI
10.1155/2012/158279
URL
http://dx.doi.org/10.1155/2012/158279
Keywords
geriatrics

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