characterization of a new flavone and tyrosinase inhibition constituents from the twigs of morus alba l.

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ID: 255561
2016
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Abstract
The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.
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zhang2016moleculescharacterization Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Long Zhang;Guanjun Tao;Jie Chen;Zong-Ping Zheng
Journal Journal of ethnopharmacology
Year 2016
DOI
10.3390/molecules21091130
URL
http://www.mdpi.com/1420-3049/21/9/1130
Keywords
phenolic compounds morus alba tyrosinase inhibitionorganic chemistry

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