effect of hydromorphone applied in the gynecological laparoscopic operation and its effect on the hemodynamics and inflammatory cytokines
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2017
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Abstract
Objective: To study the effect of hydromorphone applied in the gynecological laparoscopic
operation and analyze its effect on the hemodynamics and inflammatory cytokines. Methods:
A total of 170 patients who were underwent selective gynecological laparoscopic operation
under general anesthesia were included in the study and randomized into the observation
group (n=85) and the control group (n=85). On the basis of routine anesthesia, the patients
in the observation group were given hydromorphone, while the patients in the control group
were given fentanyl. The hemodynamic changes in different timing points in the two groups
were observed and compared. The levels of serum inflammatory cytokines and stress reaction
indicators in the two groups were detected and compared. Results: HR, SBP, and MAP at T2
in the observation group were significantly reduced when compared with at T1, those at T3
were recovered to levels at T1. HR, SBP, and MAP at T2 and T3 in the control group were
significantly reduced, and those were significantly lower than those in the observation group.
IL-6, IL-10, and TNF-α levels 24 h after anesthesia in the two groups were significantly
elevated when compared with before anesthesia. IL-10 level in the observation group was
significantly higher than that in the control group, while IL-6 and TNF-α were significantly
lower than those in the control group. CRP, FC, A, and NE levels 24 h after anesthesia in the
two groups were significantly reduced, and those in the observation group were significantly
lower than those in the control group. Conclusions: Hydromorphone applied in the
gynecological laparoscopic operation will not produce great effect on the hemodynamics, with
small stress reaction and mild inflammatory reaction; therefore, it is more beneficial for the
postoperative recovery.
| Reference Key |
shi12017journaleffect
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|---|---|
| Authors | ;Chong-Lai Shi1;Song-Tao Zhou2;Xiao-Gang Li1 |
| Journal | journal of communications |
| Year | 2017 |
| DOI |
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| URL | |
| Keywords | Keywords not found |
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