monitoring and inhibiting mt1-mmp during cancer initiation and progression

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ID: 255064
2014
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Abstract
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.
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pahwa2014cancersmonitoring Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sonia Pahwa;Maciej J. Stawikowski;Gregg B. Fields
Journal The Journal of investigative dermatology
Year 2014
DOI
10.3390/cancers6010416
URL
http://www.mdpi.com/2072-6694/6/1/416
Keywords
matrix metalloproteinases collagen cd44 Oncology including cancer and carcinogens tumors mmp-14

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