sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using α-[11c]methyl-l-tryptophan, positron emission tomography and statistical parametric mapping
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ID: 255032
2003
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Abstract
BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotransmitter found in the brain and gut, may be related to the pathophysiology of IBS. It is reported that a 5-HT3 antagonist is effective only in female patients with diarrhea-predominant IBS.
| Reference Key |
nakai2003canadiansex
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|---|---|
| Authors | ;Akio Nakai;Yoshikata Kumakura;Michel Boivin;Pedro Rosa;Mirko Diksic;Doreen D’Souza;Kathryn Kersey |
| Journal | indian journal of pharmacology |
| Year | 2003 |
| DOI |
10.1155/2003/572127
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| URL | |
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