basal cell subpopulation as putative human prostate carcinoma stem cells.

Clicks: 97
ID: 254733
2007
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Abstract
The present study examines the expression of p63, glutathione S-transferase-pi (GSTP1) and alpha-methylacyl-CoAracemase (AMACR) in serial slices in proliferative inflammatory atrophy (PIA) in order to implicate that some of the basal cells are probably the putative human prostate carcinoma stem cells (PHPCSC). Archived tissue sections obtained after radical prostatectomy from cases (n=30) comprising of PIA were tested using immunohistochemistry with antibodies against AMACR (Dako), p63 and GSTP1 (Labvision) and visualized by biotin-streptavidin-peroxidase kit (DAKO LSAB 2 kit). Quantitative immunohistochemistry analysis (QIHC) of the studied antigen expression levels revealed that there are two populations of p63 basal cells. Type I basal cells had high AMACR, low GSTP1 and p63 expression. Type II basal cells had low AMACR, high GSTP1 and p63 expression. Therefore, we propose that the putative human prostate carcinoma stem cells probably reside within the population of type I basal cells.
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todorova2007foliabasal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Krassimira Todorova;Milen Karaivanov;Soren Hayrabedyan;Aleksandar Kuzmanov
Journal reviews on recent clinical trials
Year 2007
DOI
10.5603/4535
URL
http://czasopisma.viamedica.pl/fhc/article/view/4535
Keywords
cytology

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