silk coating as a novel delivery system and reversible adhesive for stiffening and shaping flexible probes

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ID: 254272
2015
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Abstract

The performance of any implantable electrode depends not only on its recording or stimulation capabilities but also on its position in relation to the target site. Electrode displacement during or after implantation represents a major issue as it might result in tissue damage or incorrect recording or stimulation location, complicating the interpretation of experimental data. Although thin-film electrode arrays have overcome some of the main limitations of more traditional, stiffer probes, their intrinsic flexibility and unilateral contacts represent a new challenge: they tend to bend during insertion and are difficult to implant simultaneously while maintaining a specific relative position. Here, we present a method that addresses all these issues using a coating of silk fibroin, a versatile protein derived from silkworm cocoons. The method is demonstrated by acquiring electromyographic (EMG) recordings in Manduca sexta, a soft-bodied animal that exemplifies the issues of electrode insertion and placement in delicate and deformable tissues.

Reference Key
metallo2015journalsilk Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cinzia Metallo;Barry A Trimmer
Journal Health & social care in the community
Year 2015
DOI
10.14440/jbm.2015.41
URL
http://www.jbmethods.org/jbm/article/view/41
Keywords
thin films

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