KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants.

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ID: 25420
2019
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Abstract
Most manipulations that extend lifespan also increase resistance to various stress factors and environmental cues in a range of animals from yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Krüppel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. A redox-regulated KLF-1 activation and transfer to the nucleus coincides with the peak of somatic mitochondrial biogenesis that occurs around a transition from larval stage L3 to D1. We further show that KLF-1 activates genes involved in the xenobiotic detoxification programme and identified cytochrome P450 oxidases, the KLF-1 main effectors, as longevity-assurance factors of mitochondrial mutants. Collectively, these findings underline the importance of the xenobiotic detoxification in the mitohormetic, longevity assurance pathway and identify KLF-1 as a central factor in orchestrating this response.
Reference Key
herholz2019klf1nature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Herholz, Marija;Cepeda, Estela;Baumann, Linda;Kukat, Alexandra;Hermeling, Johannes;Maciej, Sarah;Szczepanowska, Karolina;Pavlenko, Victor;Frommolt, Peter;Trifunovic, Aleksandra;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-11275-w
URL
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