il-15 enhances activation and igf-1 production of dendritic epidermal t cells to promote wound healing in diabetic mice

Clicks: 166
ID: 254188
2017
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing.
Reference Key
wang2017frontiersil-15 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yangping Wang;Yang Bai;Yashu Li;Guangping Liang;Yufeng Jiang;Zhongyang Liu;Meixi Liu;Jianlei Hao;Xiaorong Zhang;Xiaorong Zhang;Xiaohong Hu;Xiaohong Hu;Jian Chen;Jian Chen;Rupeng Wang;Zhinan Yin;Jun Wu;Jun Wu;Gaoxing Luo;Gaoxing Luo;Weifeng He;Weifeng He
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.01557
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01557/full
Keywords
wound healing diabetes mellitus il-15 igf-1 allergy type 1immunologic diseases

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.