inducible and combinatorial gene manipulation in mouse brain
Clicks: 218
ID: 253722
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
218 views
30 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #212 of 394 articles by views in macromolecular bioscience
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 394 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
We have deployed recombinant adeno-associated viruses (rAAVs) equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate ‘when’, ‘where’ and ‘how’ gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.
| Reference Key |
dogbevia2015frontiersinducible
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Godwin K Dogbevia;Godwin K Dogbevia;Ricardo eMarticorena-Alvarez;Melanie eBausen;Rolf eSprengel;Mazahir T Hasan |
| Journal | macromolecular bioscience |
| Year | 2015 |
| DOI |
10.3389/fncel.2015.00142
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.