inducible and combinatorial gene manipulation in mouse brain

Clicks: 158
ID: 253722
2015
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Abstract
We have deployed recombinant adeno-associated viruses (rAAVs) equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate ‘when’, ‘where’ and ‘how’ gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.
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dogbevia2015frontiersinducible Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Godwin K Dogbevia;Godwin K Dogbevia;Ricardo eMarticorena-Alvarez;Melanie eBausen;Rolf eSprengel;Mazahir T Hasan
Journal macromolecular bioscience
Year 2015
DOI
10.3389/fncel.2015.00142
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00142/full
Keywords
neurological diseases brain circuits neuropsychiatry biological psychiatry

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