regulation of gap junction channels by infectious agents and inflammation in the cns

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ID: 252889
2014
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Abstract
Gap junctions are conglomerates of intercellular channels that connect the cytoplasm of two or more cells, and facilitate the transfer of second messengers, small peptides and RNA resulting in metabolic and electrical coordination. In general, loss of gap junctional communication (GJC) has been associated with cellular damage and inflammation resulting in compromise of physiological functions. Recently, it has become evident that gap junction channels also play a critical role in the pathogenesis of infectious diseases and associated inflammation. Several pathogens use the transfer of intracellular signals through GJ channels to spread infection and toxic signals that amplify inflammation to neighboring cells. Thus, identification of the mechanisms by which several infectious agents alter GJC could result in new potential therapeutic approaches to reduce inflammation and their pathogenesis.
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ecastellano2014frontiersregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Paul eCastellano;Eliseo eEugenin
Journal macromolecular bioscience
Year 2014
DOI
10.3389/fncel.2014.00122
URL
http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00122/full
Keywords
hiv microglia astrocytes oligodendrocytes neuropsychiatry biological psychiatry hemichannelneurosciences

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