short-term administration of serelaxin produces predominantly vascular benefits in the angiotensin ii/l-name chronic heart failure model
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2017
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Abstract
Summary: In patients hospitalized with acute heart failure, temporary serelaxin infusion reduced 6-month mortality through unknown mechanisms. This study therefore explored the cardiovascular effects of temporary serelaxin administration in mice subjected to the angiotensin II (AngII)/L-NG-nitroarginine methyl ester (L-NAME) heart failure model, both during serelaxin infusion and 19 days postâserelaxin infusion. Serelaxin administration did not alter AngII/L-NAME-induced cardiac hypertrophy, geometry, or dysfunction. However, serelaxin-treated mice had reduced perivascular left ventricular fibrosis and preserved left ventricular capillary density at both time points. Furthermore, resistance vessels from serelaxin-treated mice displayed decreased potassium chlorideâinduced constriction and reduced aortic fibrosis. These findings suggest that serelaxin improves outcomes in patients through vascular-protective effects. Key Words: heart failure, relaxin, vascular function
| Reference Key |
ms2017jacc:short-term
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| Authors | ;Joseph C. McCarthy, MS;Mark Aronovitz, MS;Jennifer J. DuPont, PhD;Timothy D. Calamaras, PhD;Iris Z. Jaffe, MD, PhD;Robert M. Blanton, MD |
| Journal | journal of nuclear materials |
| Year | 2017 |
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