diverse roles of macrophages in intraocular neovascular diseases: a review

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ID: 252377
2017
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Abstract
Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.
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zhou2017internationaldiverse Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ye-Di Zhou;Shigeo Yoshida;Ying-Qian Peng;Yoshiyuki Kobayashi;Lu-Si Zhang;Luo-Sheng Tang
Journal The Classical Review
Year 2017
DOI
10.18240/ijo.2017.12.18
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