approach to spot overlapping problem in 2d-page revealed clinical and functional significance of rkip and mnsod in renal cell carcinoma

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ID: 251694
2014
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Abstract
Previously, we identified protein spots with differential intensity between normal and tumor tissues of renal cell carcinoma (RCC) using 2D-DIGE. Here, we further examined two proteins, raf-1 kinase inhibitory protein (RKIP) and manganese superoxide dismutase (MnSOD), identified in one protein spot. Western blotting demonstrated that RKIP and MnSOD exhibited opposite expression patterns in normal and tumor tissues. Immunohistochemisry showed that MnSOD level significantly correlated with shorter progression-free survival. Gene-silencing assay demonstrated that RKIP and MnSOD had suppressive and promotive effects on tumor cell proliferation and invasion, respectively. Our findings reveal biological and clinical significance of RKIP and MnSOD in RCC.
Reference Key
hosoya2014eupaapproach Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Noriyuki Hosoya;Marimu Sakumoto;Yoshihiko Tomita;Tadashi Kondo
Journal technological and economic development of economy
Year 2014
DOI
10.1016/j.euprot.2014.06.005
URL
http://www.sciencedirect.com/science/article/pii/S2212968514000440
Keywords
Mass spectrometry renal cell carcinoma manganese superoxide dismutasegenetics

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