leucoencefalite esclerosante subaguda: estudo do proteinograma do liquido cefalorraqueano e do soro sangüíneo de 25 pacientes subacute sclerosing leucoencephalitis: electrophorectic studies of protein fractions in cerebrospinal fluid and sera in 25 patients
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ID: 251323
1968
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Abstract
Estudo do proteinograma do LCR de 25 pacientes com LEES. Em 21 deles foi analisado também o proteinograma do sôro. Em 6 casos foram analisadas as modificações do proteinograma do LCR após tempos variáveis de doença. Em um, sucessivos exames foram feitos no LCR e no sôro até a morte. Os resultados do estudo confirmam aqueles registrados na literatura, pois a hipergamaglobulinorraquia foi a principal alteração observada. Ela ocorria em todos os casos e os teores distribuíam-se entre 30 e 50% na maioria deles; o maior teor observado foi de 60%. O estudo do proteinograma do soro mostrou alterações menos intensas e menos constantes. Destacaram-se entre elas o aumento de globulina alfa-2 (14 casos) e o aumento da gama globulinemia (15 casos), discreto na maioria dos casos. A relação gama LCR/sôro mostrava-se aumentada em todos os casos; era maior que 2,0 em 7 pacientes. Os valores do índice beta/A no LCR eram iguais ou superiores à unidade em 20 casos sugerindo a vigência de comprometimento parenquimatoso por ocasião do exame. Os resultados foram relacionados ao tempo de doença por ocasião do exame.Os valores da relação gama LCR/sôro eram, em média, maiores nos casos em que a doença evoluía há mais tempo. Os valores maiores do índice beta/A ocorriam, em média, nos casos com tempo de doença menor. Considerações sôbre a utilidade do índice beta/A no LCR para avaliar a vigência de lesões encefálicas no decurso da LEES foram feitas também baseadas nos casos em que um segundo proteinograma do LCR foi estudado, bem como naquele em que sucessivos exames foram feitos até a morte.
Study of cerebrospinal fluid (CSF) protein profile in 25 patients with subacute sclerosing leucoencephalitis (SSLE) was made. Twenty-one were also tested for serum protein profile. Six were tested for changes in CSF proteins at other stages of illness. In one, successive exams were done in CSF and serum prior to death. The results of this study confirmed those already recorded, that CSF hypergammaglobulin content was the principal alteration observed. This occured in all cases with the average majority distribution being between 30-50%, high being 60%. Study of serum protein profile showed less constant and less intensive alterations: increased alpha-2 globulin content in 14 cases and gamma globulin increases in 15 cases. The latter were slight in most of the cases. The serum/CSF gamma globulin relation showed increases in all of the cases, being more than 2.0 in 7 patients. The CSF beta/albumin index was calculed as proposed in a prior publication. In 20 cases its value was one or more. Such values suggest actual damage of central nervous system on the occasion of exam. Results were related to the time of illness. The CSF/serum gamma values were, on the average, more elevated in cases where disease was more advanced. The higher values of CSF beta/albumin index occured, in general, in cases in early stages of disease. Further considerations as to the usefulness of CSF beta/albumin index in evaluation of central nervous system lesions in the course of SSLE were also done based on cases where a second CSF protein profile was performed, as well as that which was submitted to successive exams prior to death.
Study of cerebrospinal fluid (CSF) protein profile in 25 patients with subacute sclerosing leucoencephalitis (SSLE) was made. Twenty-one were also tested for serum protein profile. Six were tested for changes in CSF proteins at other stages of illness. In one, successive exams were done in CSF and serum prior to death. The results of this study confirmed those already recorded, that CSF hypergammaglobulin content was the principal alteration observed. This occured in all cases with the average majority distribution being between 30-50%, high being 60%. Study of serum protein profile showed less constant and less intensive alterations: increased alpha-2 globulin content in 14 cases and gamma globulin increases in 15 cases. The latter were slight in most of the cases. The serum/CSF gamma globulin relation showed increases in all of the cases, being more than 2.0 in 7 patients. The CSF beta/albumin index was calculed as proposed in a prior publication. In 20 cases its value was one or more. Such values suggest actual damage of central nervous system on the occasion of exam. Results were related to the time of illness. The CSF/serum gamma values were, on the average, more elevated in cases where disease was more advanced. The higher values of CSF beta/albumin index occured, in general, in cases in early stages of disease. Further considerations as to the usefulness of CSF beta/albumin index in evaluation of central nervous system lesions in the course of SSLE were also done based on cases where a second CSF protein profile was performed, as well as that which was submitted to successive exams prior to death.
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| Authors | ;A. Spina-França;W. A. Tognola;A. Xavier-Lima |
| Journal | communications in computer and information science |
| Year | 1968 |
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