modelo experimental de aneurisma sacular de artéria ilíaca comum com pericárdio bovino em suínos experimental model of saccular aneurysm of the common iliac artery with bovine pericardium in pigs

Clicks: 268
ID: 250820
2005
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Abstract
OBJETIVO: Desenvolver um novo modelo experimental de pseudoaneurisma sacular de artéria ilíaca comum com o uso de remendo de pericárdio bovino em suínos. MÉTODO: Foram utilizados dois suínos da raça Landrace, com peso de 30 kg e do sexo feminino. Os animais foram submetidos a anestesia geral e a laparotomia com acesso extraperitoneal da aorta infra-renal e artérias ilíacas. Após heparinização sistêmica e pinçamento, foram efetuadas arteriotomia longitudinal e sutura do pericárdio bovino em formato de bolsa previamente confeccionada. Os animais permaneceram confinados por 3 semanas e então foram submetidos a arteriografia para avaliação da perviedade do aneurisma e, posteriormente, sacrificados. RESULTADO: Os animais sobreviveram ao experimento e apresentaram aneurismas pérvios no momento do sacrifício. Não houve ocorrência de ruptura de aneurismas. CONCLUSÃO: O modelo proposto é viável e tem potencial para ser utilizado no estudo e desenvolvimento de novas próteses endovasculares.
OBJECTIVE: To develop an experimental model of saccular pseudoaneurysm of the common iliac artery with bovine pericardium in pigs. METHOD: The animals used were two 30-kg female pigs from the Landrace specimen. The animals were submitted to general anesthesia and laparotomy with extraperitoneal access to infrarenal aorta and the iliac arteries. After systemic heparin and clamping, the iliac artery was opened and the pericardium sutured to the vessel wall. All animals were confined for 3 weeks and were sacrificed after performing an arteriography to verify the patency of the aneurysm. RESULT: All animals survived the procedure and the aneurysms were patent. No rupture was detected. CONCLUSION: This is a feasible pig model of iliac artery aneurysm with potential for further studies to develop new endovascular prostheses.
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Authors ;Luís Henrique Gil França;Adamastor Humberto Pereira;Sílvio César Perini;Rodrigo Argenta;Celso Curcio Aveline;Roseli de Oliveira Mollerke;Marcos Eugenio Soares;Fernanda Nóbrega;Márcio Poletto Ferreira
Journal medecine et sante tropicales
Year 2005
DOI
10.1590/S1677-54492005000400010
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492005000400010
Keywords
aortic aneurysm arteries animal modelssurgerydiseases of the circulatory (cardiovascular) system

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