microglia after seizures and in epilepsy

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ID: 250676
2018
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Abstract
Microglia are the resident immune cells in the brain that constitute the brain’s innate immune system. Recent studies have revealed various functions of microglia in the development and maintenance of the central nervous system (CNS) in both health and disease. However, the role of microglia in epilepsy remains largely undiscovered, partly because of the complex phenotypes of activated microglia. Activated microglia likely exert different effects on brain function depending on the phase of epileptogenesis. In this review, we mainly focus on the animal models of temporal lobe epilepsy (TLE) and discuss the proepileptic and antiepileptic roles of activated microglia in the epileptic brain. Specifically, we focus on the roles of microglia in the production of inflammatory cytokines, regulation of neurogenesis, and surveillance of the surrounding environment in epilepsy.
Reference Key
hiragi2018cellsmicroglia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Toshimitsu Hiragi;Yuji Ikegaya;Ryuta Koyama
Journal Frontiers in psychology
Year 2018
DOI
10.3390/cells7040026
URL
http://www.mdpi.com/2073-4409/7/4/26
Keywords
epilepsy microglia seizure glia epileptogenesis

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