abnormal white matter integrity in chinese young adults with first-episode medication-free anxious depression: a possible neurological biomarker of subtype major depressive disorder

Klik: 373
ID: 250513
2018
PDF Gratis
Metrik Kualitas & Kinerja Artikel
Kualitas Keseluruhan
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
Penilaian Kualitas AI
Belum dianalisis
Readership in this journal
Emerging

Ranked #7 of 117 articles by views in journal of crystal growth

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstrak
Weiping Xia,1,2 Rubai Zhou,1 Guoqing Zhao,1 Fan Wang,1 Ruizhi Mao,1 Daihui Peng,1 Tao Yang,1 Zuowei Wang,1,3 Jun Chen,1 Yiru Fang1,4,5 1Division of Mood Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Medical Psychology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Mood Disorder Department, Hongkou District Mental Health Center of Shanghai, Shanghai, People’s Republic of China; 4State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, CAS, Shanghai, People’s Republic of China; 5Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People’s Republic of China Background: Almost half of patients with major depressive disorder (MDD) also have clinically meaningful levels of anxiety. Anxious depression is a distinct clinical subtype of MDD, which has poor response to pharmacotherapy; however, the neural mechanisms behind are largely unknown. In the present study, we explored the white matter (WM) integrity traits of anxious depression in first-episode and medication-free (medication-naïve and medication washout) Chinese young adult patients by detecting differences in diffusion tensor imaging (DTI) with the tract-based spatial statistics (TBSS) method.Subjects and methods: DTI was obtained from 39 first-episode, medication-free anxious depressive patients, 45 nonanxious depressive patients, and 50 demographically similar healthy controls. All subjects underwent clinical assessments. TBSS was carried out to investigate the difference in WM integrity among three groups within DTI parameter maps. WM integrity was measured using fractional anisotropy (FA), mean diffusivity, axial diffusivity, and radial diffusivity (RD). The correlations between WM integrity and clinical features were also computed.Results: When compared with nonanxious patients, lower FA values in anxious depressive patients were found in multiple regions of the brain, mainly involving left uncinate fasciculus (UF), superior longitudinal fasciculus (SLF), and forceps major and minor. Higher RD in forceps major and minor and SLF were also detected. The decreased FA values and increased RD values correlated with both anxiety level and depression level in the pooled depressive group.Conclusion: The anxious depressive patients had more abnormalities in WM integrity at the early phase than the nonanxious group. Alternations in WM integrity in fiber pathways, including SLF, UF, and forceps major and minor, may play a critical role in the neuropathology of anxious depression and might help to identify anxious MDD from nonanxious MDD. Further study with larger sample size, larger age range, and longitudinal design is needed to confer a robust inference to better understand the dynamic neurological change and neuropathology of WM integrity in anxious MDD. Keywords: diffusion tensor imaging, anxious depression, tract-based spatial statistics, micro-structure of whiter matter
Kunci Referensi
w2018neuropsychiatricabnormal Gunakan kunci ini untuk mengutip otomatis dalam naskah saat menggunakan SciMatic Manuscript Manager atau Thesis Manager
Penulis ;Xia W;Zhou R;Zhao G;Wang F;Mao R;Peng D;Yang T;Wang Z;Chen J;Fang Y
Jurnal journal of crystal growth
Tahun 2018
DOI
DOI tidak ditemukan
URL
https://www.dovepress.com/abnormal-white-matter-integrity-in-chinese-young-adults-with-first-epi-peer-reviewed-article-NDT
Kata Kunci
white matter diffusion tensor imaging functional magnetic resonance imaging neurosciences diseases of the nervous system neuropsychiatryneurology biological psychiatry neuropsychiatryneurology spontaneous brain activity blood oxygen-level-dependent

Sitasi

Tidak ada sitasi yang ditemukan. Untuk menambahkan sitasi, hubungi admin di info@scimatic.org

Komentar

Belum ada komentar. Jadilah yang pertama berkomentar pada artikel ini.