proliferative tumor doubling times of prostatic carcinoma

Clicks: 185
ID: 250416
2011
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Abstract
Prostate cancer (PCa) has a variable biology ranging from latent cancer to extremely aggressive tumors. Proliferative activities of cancers may indicate their biological potential. A flow cytometric assay to calculate maximum proliferative doubling times (Tmax) of PCa in radical prostatectomy specimens after preoperative in vivo bromodeoxyuridine (BrdU) infusion is presented. Only 4/17 specimens had tumors large enough for flow cytometric analysis. The Tmax of tumors was similar and ranged from 0.6 to 3.6 months. Tumors had calculated doubling times 2- to 25-fold faster than their matched normal tissue. Variations in labeling index and Tmax were observed within a tumor as well as between different Gleason grades. The observed PSA doubling times (PSA-DT) ranged from 18.4 to 32.0 months, considerably slower than the corresponding Tmax of tumors involved. While lack of data for apoptotic rates is a limitation, apparent biological differences between latent versus aggressive PCa may be attributable to variations in apoptotic rates of these tumors rather than their cell proliferative rates.
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werahera2011prostateproliferative Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Priya N. Werahera;L. Michael Glode;Francisco G. La Rosa;M. Scott Lucia;E. David Crawford;Kenneth Easterday;Holly T. Sullivan;Rameshwar S. Sidhu;Elizabeth Genova;Tammy Hedlund
Journal seminars in radiation oncology
Year 2011
DOI
10.1155/2011/301850
URL
http://dx.doi.org/10.1155/2011/301850
Keywords
Oncology including cancer and carcinogens tumors diseases of the genitourinary system urologyneoplasms

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