single-shot t1 mapping of the corpus callosum: a rapid characterization of fiber bundle anatomy
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2015
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Abstract
Using diffusion-tensor MRI and fiber tractography the topographic organization of the corpus callosum (CC) has been described to comprise 5 segments with fibers projecting into prefrontal (I), premotor and supplementary motor (II), primary motor (III), and primary sensory areas (IV), as well as into parietal, temporal, and occipital cortical areas (V). In order to more rapidly characterize the underlying anatomy of these segments, this study used a novel single-shot T1 mapping method to quantitatively determine T1 relaxation times in the human CC. A region-of-interest analysis revealed a tendency for the lowest T1 relaxation times in the genu and the highest T1 relaxation times in the somatomotor region of the CC. This observation separates regions dominated by myelinated fibers with large diameters (somatomotor area) from densely packed smaller axonal bundles (genu) with less myelin. The results indicate that characteristic T1 relaxation times in callosal profiles provide an additional means to monitor differences in fiber anatomy, fiber density, and gray matter in respective neocortical areas. In conclusion, rapid T1 mapping allows for a characterization of the axonal architecture in an individual CC in less than 10 s. The approach emerges as a valuable means for studying neocortical brain anatomy with possible implications for the diagnosis of neurodegenerative processes.
| Reference Key |
ehofer2015frontierssingle-shot
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|---|---|
| Authors | ;Sabine eHofer;Sabine eHofer;Xiaoqing eWang;Volkert eRoeloffs;Jens eFrahm;Jens eFrahm |
| Journal | Journal of medical systems |
| Year | 2015 |
| DOI |
10.3389/fnana.2015.00057
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