supplemental cellular protection by a carotenoid extends lifespan via ins/igf-1 signaling in caenorhabditis elegans
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2011
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Abstract
Astaxanthin (AX), which is produced by some marine animals, is a type of carotenoid that has antioxidative properties. In this study, we initially examined the effects of AX on the aging of a model organism C. elegans that has the conserved intracellular pathways related to mammalian longevity. The continuous treatments with AX (0.1 to 1 mM) from both the prereproductive and young adult stages extended the mean lifespans by about 16–30% in the wild-type and long-lived mutant age-1 of C. elegans. In contrast, the AX-dependent lifespan extension was not observed even in a daf-16 null mutant. Especially, the expression of genes encoding superoxide dismutases and catalases increased in two weeks after hatching, and the DAF-16 protein was translocated to the nucleus in the AX-exposed wild type. These results suggest that AX protects the cell organelle mitochondria and nucleus of the nematode, resulting in a lifespan extension via an Ins/IGF-1 signaling pathway during normal aging, at least in part.
| Reference Key |
yazaki2011oxidativesupplemental
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|---|---|
| Authors | ;Koumei Yazaki;Chinatsu Yoshikoshi;Satoru Oshiro;Sumino Yanase |
| Journal | journal of aoac international |
| Year | 2011 |
| DOI |
10.1155/2011/596240
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