the role of single nucleotide polymorphisms of cytokine genes in viral infections

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ID: 249653
2014
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Abstract
Gene polymorphisms result from evolutionary processes representing mutations that survive in the population with a frequency higher than 1%. The most investigated type of gene polymorphisms are single nucleotide polymorphisms (SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney graft CMV-seropositive recipients have an impact on a clinical events in cytomegalovirus (CMV) disease. Constitutive -308 G/A TNF-α polymorphism (rs1800629) is related to the susceptibility of HR-HPV-associated cervical dysplasia and cancer. SNP located 3 kb upstream of the IL- 28B gene (rs12979860) seems to be the strongest host genetic predictor of sustained virologic response (SVR) in hepatitis C genotype 1 patients. It is very important to identify viral and host genetic markers that may facilitate the risk of developing viral disease or some viral-associated cancers. In addition, these markers could be useful in the choice of effective treatments and preventive strategies against virally induced infection. [Projekat Ministarstva nauke Republike Srbije, br. 175073 i br. 175038]
Reference Key
maja2014archivesthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ćupić Maja;Pravica Vera;Lazarević Ivana;Banko Ana;Karalić Danijela;Tasić Dijana;Jovanović Tanja
Journal gastrointestinal endoscopy
Year 2014
DOI
10.2298/ABS1402595C
URL
http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402595C.pdf
Keywords
TNF-α hepatitis c hpv cervical cancer snp cmv svrbiology (general)

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