the role of single nucleotide polymorphisms of cytokine genes in viral infections
Clicks: 288
ID: 249653
2014
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Emerging Content
6.9
/100
23 views
23 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Gene polymorphisms result from evolutionary processes representing mutations
that survive in the population with a frequency higher than 1%. The most
investigated type of gene polymorphisms are single nucleotide polymorphisms
(SNPs). The SNPs of IL-12B (rs 3212227) A/C among a population of kidney
graft CMV-seropositive recipients have an impact on a clinical events in
cytomegalovirus (CMV) disease. Constitutive -308 G/A TNF-α polymorphism
(rs1800629) is related to the susceptibility of HR-HPV-associated cervical
dysplasia and cancer. SNP located 3 kb upstream of the IL- 28B gene
(rs12979860) seems to be the strongest host genetic predictor of sustained
virologic response (SVR) in hepatitis C genotype 1 patients. It is very
important to identify viral and host genetic markers that may facilitate the
risk of developing viral disease or some viral-associated cancers. In
addition, these markers could be useful in the choice of effective treatments
and preventive strategies against virally induced infection. [Projekat
Ministarstva nauke Republike Srbije, br. 175073 i br. 175038]
| Reference Key |
maja2014archivesthe
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Ćupić Maja;Pravica Vera;Lazarević Ivana;Banko Ana;Karalić Danijela;Tasić Dijana;Jovanović Tanja |
| Journal | gastrointestinal endoscopy |
| Year | 2014 |
| DOI |
10.2298/ABS1402595C
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.