simple approach for ranking structure determining residues

Clicks: 186
ID: 249606
2016
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Abstract
Mutating residues has been a common task in order to study structural properties of the protein of interest. Here, we propose and validate a simple method that allows the identification of structural determinants; i.e., residues essential for preservation of the stability of global structure, regardless of the protein topology. This method evaluates all of the residues in a 3D structure of a given globular protein by ranking them according to their connectivity and movement restrictions without topology constraints. Our results matched up with sequence-based predictors that look up for intrinsically disordered segments, suggesting that protein disorder can also be described with the proposed methodology.
Reference Key
luna-martnez2016peerjsimple Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Oscar D. Luna-Martínez;Abraham Vidal-Limón;Miryam I. Villalba-Velázquez;Rosalba Sánchez-Alcalá;Ramón Garduño-Juárez;Vladimir N. Uversky;Baltazar Becerril
Journal pediatrics
Year 2016
DOI
10.7717/peerj.2136
URL
https://peerj.com/articles/2136/
Keywords
molecular dynamics intrinsic disorder

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