monitoração molecular da leucemia mielóide crônica na era do imatinibe molecular monitoring of chronic myeloid leukemia in the imatinib era
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Abstract
Treatment of chronic myeloid leukemia (CML) has changed since the introduction of imatinib mesylate (IM) 10 years ago. IM acts as a target therapy against the BCR-ABL gene by inhibiting its tyrosine kinase activity. This revolution in treating CML compels the introduction of molecular techniques, such as real time quantitative polymerase chain reaction (RQ-PCR) to monitor the response to IM by providing an accurate measurement of the degree to which the BCR-ABL transcript is reduced or an early detection of loss of response identified by a rising level of BCR-ABL. In this review, we summarize the Brazilian CML consensus regarding the main procedures used to monitor CML patients treated with IM.
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bendit2008revistamonitorao
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| Authors | ;Israel Bendit |
| Journal | journal of computational and graphical statistics : a joint publication of american statistical association, institute of mathematical statistics, interface foundation of north america |
| Year | 2008 |
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