il-13 signaling in liver fibrogenesis
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ID: 247850
2012
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Abstract
Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis associated genes, e.g. collagens or connective tissue growth factor, by hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis start to be uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis.
| Reference Key |
eliu2012frontiersil-13
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|---|---|
| Authors | ;Yan eLiu;Stefan eMunker;Roman eMüllenbach;Roman eMüllenbach;Honglei eWeng |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2012 |
| DOI |
10.3389/fimmu.2012.00116
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| URL | |
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