radioimmunoguided surgery for colorectal cancer - an overview
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ID: 247687
1990
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Abstract
Many different monoclonal antibodies used experimentally and
clinically are highly tumour-specific. Radiolahelling of these antibodies has been
successfully accomplished. lmmunoscintigraphy of primary and metastatic cancers
has a reported sensitivity of 59 to 70%. However, in many studies, operative
and histologic confirmation is lacking. Radioimmunoguided surgery is a promising
new adjunctive technique for the surgical treatment of colorectal cancer. Its
reported sensitivity ranges between 70 and 100% and specificity between 66 and
100%. In approximately one-third of patients wirh colorectal cancer, additional
intraoperative information concerning the presence of subclinical tumours was
gained using radioimmunoguided surgery. This system has the potential to assist
the surgeon in performing complete resection of cancer and decrease the local
recurrence rate. This could be of particular clinical importance for rectosigmoid
tumours where the reported local recurrence rate is as high as 30%. Despite the
advances made, many problems still need to be resolved. The important ones
include: finding an antibody with high tumour specificity and at the same time
rapid clearance from the blood pool and normal tissue - this would avoid the
delay between monoclonal antibody injection and surgery and would make this
approach more easily accepted by the patient; and use of alternative isotopes for
radiolabelling. Radioimmunoguided surgery has the potential to change the way
surgery for colorectal cancer is being performed. It offers the possibility of
improvement in patient survival.
| Reference Key |
brzezinski1990canadianradioimmunoguided
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|---|---|
| Authors | ;Wojciech Brzezinski;Olin G Thurston;Ernest Wiens |
| Journal | indian journal of pharmacology |
| Year | 1990 |
| DOI |
10.1155/1990/420697
|
| URL | |
| Keywords |
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