association of apolipoprotein e-219t>g promoter polymorphism with primary open angle glaucoma in turkish population

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ID: 247653
2014
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Abstract
AIM: To investigate the association between apolipoprotein E (APOE) -219 T>G promoter polymorphism and primary open angle glaucoma (POAG).METHODS: Patients and healthy subjects were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotype/allele frequencies were compared between 122 healthy subjects and in 75 POAG patients using Chi-square test.RESULTS:Although the frequency of APOE -219 GG genotype was higher in POAG group (13.3%) than in control group (6.6%), this finding was not statistically significant (P=0.09). In glaucoma patients carrying GG genotype, mean linear C/D ratio was higher and progression was more compared to glaucoma patients with GT genotype.CONCLUSION: APOE -219 T>G polymorphism does not seem to be a risk factor for the presence of glaucoma, but might play a role in deterioration of the disease, which needs further evaluation.
Reference Key
saglar2014internationalassociation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Emel Saglar;Banu Bozkurt;Murat Irkec
Journal The Classical Review
Year 2014
DOI
10.3980/j.issn.2222-3959.2014.03.07
URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067653/
Keywords
single nucleotide polymorphism apolipoprotein e promoter

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