multifaceted adult t-cell leukemia/lymphoma in india: a case series

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ID: 246122
2015
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Abstract
Background : Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). India is considered as a nonendemic region for HTLV-1. Recent upsurge of cases have been noted in southern parts of India. Aims and objectives: The objective was to describe skin manifestations in various types of ATL. Materials and Methods: Clinical examination, blood investigations, skin biopsies, lymph node biopsies, and immunohistochemistry were performed in five patients. Flow cytometry was performed in two cases. Results: Serological testing was positive for HTLV-1 in all patients. All patients presented with skin lesions. Rare presentations of molluscum contagiosum like papules, purpuric macules and plaques, hypopigmented macules and verrucous papules were seen. Dermatophytic infections occurred in two patients. Mucosal lesion was seen in one patient. Histological features include dermal lymphoid infiltrate with or without epidermotropism. Presence of epidermotropism did not correlate with the severity of disease. All patients except one succumbed to illness within few months to 1 year period. Conclusions: ATL manifest in myriad presentations and skin lesions are often the earliest manifestation. Cutaneous manifestations of ATL vary from subtle hypopigmented macules to florid nodular lesions, and HTLV-1 screening need to be carried out in all doubtful cases.
Reference Key
khader2015indianmultifaceted Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Anza Khader;Mohamed Shaan;Sunitha Balakrishnan;Betsy Ambooken;Kunnummel Muhammed;Uma Rajan
Journal heterocycles
Year 2015
DOI
10.4103/0019-5154.147846
URL
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=1;spage=103;epage=103;aulast=Khader
Keywords
india adult t-cell leukemia/lymphoma skin lesions dermatology

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