a potent (r)-alpha-bis-lipoyl derivative containing 8-hydroxyquinoline scaffold: synthesis and biological evaluation of its neuroprotective capabilities in sh-sy5y human neuroblastoma cells
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ID: 245742
2013
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Abstract
A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H2O2 on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H2O2- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
| Reference Key |
cacciatore2013pharmaceuticalsa
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|---|---|
| Authors | ;Ivana Cacciatore;Erika Fornasari;Leonardo Baldassarre;Catia Cornacchia;Stefania Fulle;Ester Sara Di Filippo;Tiziana Pietrangelo;Francesco Pinnen |
| Journal | journal of cerebral blood flow and metabolism |
| Year | 2013 |
| DOI |
10.3390/ph6010054
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| URL | |
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