a potent (r)-alpha-bis-lipoyl derivative containing 8-hydroxyquinoline scaffold: synthesis and biological evaluation of its neuroprotective capabilities in sh-sy5y human neuroblastoma cells

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ID: 245742
2013
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Abstract
A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H2O2 on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H2O2- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
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cacciatore2013pharmaceuticalsa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ivana Cacciatore, Erika Fornasari, Leonardo Baldassarre, Catia Cornacchia, Stefania Fulle, Ester Sara Di Filippo, Tiziana Pietrangelo, Francesco Pinnen
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Journal journal of cerebral blood flow and metabolism
Year 2013
DOI
10.3390/ph6010054
URL
http://www.mdpi.com/1424-8247/6/1/54
Keywords
8-hydroxyquinoline antioxidants

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