early bcr events and antigen capture, processing and loading on mhc class ii on b cells
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ID: 245061
2014
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Abstract
B cells are efficient antigen presenting cells (APCs) by means of antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review we describe the steps required for antigen uptake, processing and loading onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.
| Reference Key |
avalos2014frontiersearly
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|---|---|
| Authors | ;Ana Maria Avalos;Hidde ePloegh |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2014 |
| DOI |
10.3389/fimmu.2014.00092
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