identification of trombospondin-1 as a novel amelogenin interactor by functional proteomics

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ID: 244367
2017
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Abstract
Amelogenins are a set of low molecular-weight enamel proteins belonging to a group of extracellular matrix (ECM) proteins with a key role in tooth enamel development and in other regeneration processes, such as wound healing and angiogenesis. Since only few data are actually available to unravel amelogenin mechanism of action in chronic skin healing restoration, we moved to the full characterization of the human amelogenin isoform 2 interactome in the secretome and lysate of Human Umbilical Vein Endothelial cells (HUVEC), using a functional proteomic approach. Trombospondin-1 has been identified as a novel and interesting partner of human amelogenin isoform 2 and their direct binding has been validated thought biophysical orthogonal approaches.
Reference Key
capolupo2017frontiersidentification Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Angela Capolupo;Angela Capolupo;Chiara Cassiano;Agostino Casapullo;Giuseppina Andreotti;Maria V. Cubellis;Andrea Riccio;Raffaele Riccio;Maria C. Monti
Journal spatium
Year 2017
DOI
10.3389/fchem.2017.00074
URL
http://journal.frontiersin.org/article/10.3389/fchem.2017.00074/full
Keywords
protein-protein interaction amelogenin

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