Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle.

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ID: 2438
2019
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Abstract
Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and is widely used as an analgesic and anti-inflammatory agent. Herein, we found that DCF could relax high K (80 mM K)-/ACh-precontracted tracheal rings (TRs) in mice. This study aimed to elucidate the underlying mechanisms of DCF-induced relaxations. The effects of DCF on airway smooth muscle (ASM) cells were explored using multiple biophysiological techniques, such as isometric tension measurement and patch-clamping experiments. Both high K- and ACh-evoked contraction of TRs in mice were relaxed by DCF in a dose-dependent manner. The results of isometric tension and patch-clamping experiments demonstrated that DCF-induced relaxation in ASM cells was mediated by cytosolic free Ca, which was decreased via inhibition of voltage-dependent L-type Ca channels (VDLCCs), nonselective cation channels (NSCCs), and NaCa exchange. Meanwhile, DCF also enhanced large conductance Ca activated K (BK) channels, which led to the relaxation of ASMs. Our data demonstrated that DCF relaxed ASMs by decreasing the intracellular Ca concentration via inhibition of Ca influx and Na/Ca exchange. Meanwhile, the enhanced BK channels also played a role in DCF-induced relaxation in ASMs. These results suggest that DCF is a potential candidate for antibronchospasmic drugs used in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease.
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chen2019relaxantfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chen, Chunfa;Yang, Yongle;Yu, Meng-Fei;Shi, Shunbo;Han, Shuhui;Liu, Qing-Hua;Cai, Congli;Shen, Jinhua;
Journal Frontiers in pharmacology
Year 2019
DOI
10.3389/fphar.2019.00608
URL
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