aberrant signaling pathways in glioma

Clicks: 212
ID: 243577
2011
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Abstract
Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and lethal primary brain tumor in adults; few treatments are available. Median survival rates range from 12–15 months. The biological characteristics of this tumor are exemplified by prominent proliferation, active invasiveness, and rich angiogenesis. This is mainly due to highly deregulated signaling pathways in the tumor. Studies of these signaling pathways have greatly increased our understanding of the biology and clinical behavior of GBM. An integrated view of signal transduction will provide a more useful approach in designing novel therapies for this devastating disease. In this review, we summarize the current understanding of GBM signaling pathways with a focus on potential molecular targets for anti-signaling molecular therapies.
Reference Key
nakada2011cancersaberrant Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mitsutoshi Nakada;Daisuke Kita;Takuya Watanabe;Yutaka Hayashi;Jun-Ichiro Hamada;Ilya V. Pyko;Lei Teng
Journal The Journal of investigative dermatology
Year 2011
DOI
10.3390/cancers3033242
URL
http://www.mdpi.com/2072-6694/3/3/3242/
Keywords
Invasion glioblastoma proliferation angiogenesis signaling Oncology including cancer and carcinogens tumors molecular targetneoplasms

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