under pressure: mechanical stress management in the nucleus
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ID: 243496
2016
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Abstract
Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.
| Reference Key |
belaadi2016cellsunder
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|---|---|
| Authors | ;Néjma Belaadi;Julien Aureille;Christophe Guilluy |
| Journal | Frontiers in psychology |
| Year | 2016 |
| DOI |
10.3390/cells5020027
|
| URL | |
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