efeito da colestase nos aspectos funcionais e morfológicos renais após nefrectomia effect of cholestasis on renal morphological and functional aspects after nephrectomy
Clicks: 334
ID: 241761
2008
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
334 views
62 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #34 of 280 articles by views in acta crystallographica section e
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 280 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJETIVOS: O crescimento de um rim em resposta à perda do outro rim recebe o nome de hipertrofia renal compensatória. Entretanto, os mecanismos que regulam esse processo ainda não foram esclarecidos. Neste estudo, avaliaram-se os efeitos da icterícia obstrutiva na morfologia e na função do rim remanescente após nefrectomia unilateral. MÉTODOS: Foram estudados 40 ratos Wistar (250g-300 g), distribuídos nos seguintes grupos: Grupo 1 - operação simulada; Grupo 2 - nefrectomia direita; Grupo 3 - ligadura do ducto biliar; Grupo 4 - ligadura do ducto biliar e nefrectomia direita. Os animais foram mortos após 20 dias, quando foi colhido sangue para exames laboratoriais e feita a retirada dos rins e do fígado. Os rins foram pesados para avaliação do crescimento compensatório. Rins e fígado foram estudados histologicamente por microscopia óptica. RESULTADOS: Não houve diferença no aumento do peso renal relativo entre os animais dos Grupos 2 e 4 (p = 0,4). Os animais submetidos à ligadura do ducto biliar isoladamente (Grupo 3) apresentaram maior peso renal relativo quando comparados com os animais submetidos à operação simulada (Grupo 1) (p = 0,011). As alterações histológicas encontradas foram dilatação capilar da camada medular nos rins hipertrofiados e modificações típicas de colestase nos fígados dos animais ictéricos. Cirrose foi encontrada apenas nos animais submetidos à nefrectomia. CONCLUSÃO: O peso e a função do rim remanescente após nefrectomia unilateral não são afetados pela icterícia obstrutiva.
OBJECTIVE: The removal of one kidney results in a compensatory growth of the remnant kidney. However, the mechanism that underlies this hypertrophic response is not understood. In this study we assessed the influence of obstructive jaundice on renal morphology and function after unilateral nephrectomy. METHODS: Forty Wistar rats (250-300 g) were randomly divided into four groups: Group 1 - sham operation, Group 2 - right nephrectomy, Group 3 - common bile duct ligation, Group 4 - common bile duct ligation and right nephrectomy. After 20 days, blood was collected for biochemical studies and the animals were killed. Their kidneys and livers were removed and weighed. Histological evaluation of both organs was carried out. RESULTS: No difference in the kidney/body weight ratio was observed for animals undergoing right nephrectomy (Groups 2 and 4) (p = 0.4). Animals submitted to bile duct ligation only (Group 3) presented a higher kidney/body weight ratio than animals submitted to sham operation (Group 1) (p = 0.011). Vasodilatation was identified in the medulla of the hypertrophied kidneys and histological alterations were found in the livers of the jaundiced animals. Cirrhosis occurred only in nephrectomized rats. CONCLUSION: Cholestasis does not affect the weight, function or the compensatory renal growth of the remnant kidney after unilateral nephrectomy.
OBJECTIVE: The removal of one kidney results in a compensatory growth of the remnant kidney. However, the mechanism that underlies this hypertrophic response is not understood. In this study we assessed the influence of obstructive jaundice on renal morphology and function after unilateral nephrectomy. METHODS: Forty Wistar rats (250-300 g) were randomly divided into four groups: Group 1 - sham operation, Group 2 - right nephrectomy, Group 3 - common bile duct ligation, Group 4 - common bile duct ligation and right nephrectomy. After 20 days, blood was collected for biochemical studies and the animals were killed. Their kidneys and livers were removed and weighed. Histological evaluation of both organs was carried out. RESULTS: No difference in the kidney/body weight ratio was observed for animals undergoing right nephrectomy (Groups 2 and 4) (p = 0.4). Animals submitted to bile duct ligation only (Group 3) presented a higher kidney/body weight ratio than animals submitted to sham operation (Group 1) (p = 0.011). Vasodilatation was identified in the medulla of the hypertrophied kidneys and histological alterations were found in the livers of the jaundiced animals. Cirrhosis occurred only in nephrectomized rats. CONCLUSION: Cholestasis does not affect the weight, function or the compensatory renal growth of the remnant kidney after unilateral nephrectomy.
| Reference Key |
lima2008revistaefeito
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Daniel Xavier Lima;Andy Petroianu;Kelly Cristine de Lacerda Rodrigues;Paulo Guilherme de Oliveira Salles |
| Journal | acta crystallographica section e |
| Year | 2008 |
| DOI |
10.1590/S0104-42302008000600015
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.